The 2008 Mercedes-Benz R-Class loses its V8 and high-performance models, but gains a version with rear-wheel drive. This slow-selling wagon is the larger of Mercedes's two midsize SUVs. It shares its basic design with the M-Class and offers seating for up to seven passengers. R-Class is also about 12 inches longer in wheelbase and 15 inches longer overall than the M-Class.

Two models are offered versus four from last year. The R350 has a 268-hp 3.5-liter V6 engine. A lower cost rear-drive R350 joins the pricier all-wheel-drive version as a new addition. The R320 CDI is AWD only and has a 215-hp 3.0-liter turbodiesel V6. All R-Class models have a 7-speed automatic transmission. The V8-powered R500 and high-performance R63 AMG models have been discontinued. Seating is available as a 2-2-2 arrangement, with folding 2nd-row bucket seats and a folding 50/50 split 3rd-row bench. A 2nd-row bench is available for seven-passenger capacity. Available safety features include ABS, traction control, antiskid system, curtain side airbags, and front and rear side airbags.