The 2008 Mercedes-Benz E-Class gets no major changes. It continues in sedan and wagon body styles available in rear-wheel-drive or all-wheel-drive versions. Four models are offered. E350s have a 268-hp 3.5-liter V6. E550s have a 382-hp V8. The E320 Bluetec has a 210-hp V6 turbodiesel. The high-performance E63 has a 507-hp V8 along with a sport suspension. All rear-drive models have a 7-speed automatic transmission; E63 adds manual-shift steering-wheel buttons. AWD models have a 5-speed automatic. Available safety features include ABS, traction control, antiskid system, curtain side airbags, and front and rear side airbags. An air suspension with driver-adjustable shock absorbers is standard on E550 and E63. Mercedes' 4Matic AWD is available on E350 and E550.

All E-Class models are available as sedans; the E350 and E63 are also available in wagon form. Available for E350 and E550 is a Sport Package that includes lowered suspension, 18-inch wheels, and unique trim. Other options include steering-linked bi-xenon headlamps and adaptive cruise control. Also available: a wireless cell phone link, navigation system, heated and ventilated front seats, and keyless access and starting. Rear obstacle detection is available for sedans. So is Mercedes' full-length Panorama glass roof with a power tilt and slide panel above the front seats.