The 2008 Lexus LS is largely unchanged. Three models are offered. There is the regular-length 460, and the 460 L and hybrid 600h L that add 4.8 inches of wheelbase and overall length. 460 models have a 380-hp 4.6-liter V8 and an 8-speed automatic transmission. The 600h has a 438-hp 5.0-liter V8 and a continuously variable automatic transmission (CVT). Available safety features include ABS, traction control, an antiskid system, front side airbags, rear side airbags, curtain airbags, and front knee airbags. Air suspension with driver-selectable firmness is optional on 460 L, standard on 600h. A keyless entry and starting system with a pocket transmitter and steering-linked headlights are standard.

Option groups include the base model's Comfort Package with heated and cooled front seats, heated rear seats, heated steering wheel, and rear power sunshade. The base model's Comfort Plus Package adds power rear seats and rear side airbags. Available for 460 L and standard on 600h is a Rear Seat Upgrade Package that includes a cooled rear console and four-zone climate control that reacts to occupants' body temperature. Also offered on 460 L and 600h is an Executive Class Seating Package that changes the seating configuration to four passengers and adds a retractable table, DVD entertainment, and a reclining, massaging right-rear seat.

Optional on base, and standard on 460 L and 600h is a navigation system with a rearview camera and a wireless cell phone link. Available for 460 models and standard on 600h is Lexus's Pre-Collision Safety System. Packaged with adaptive cruise control, it automatically tightens the seatbelts and readies full braking power when sensors detect an imminent collision. Also available is Lexus's Advanced Parking Guidance System, which provides hands-free parallel parking.