Diesel and high-performance models join the larger of Mercedes' two midsize SUVs for 2007. R-Class shares its basic structure with Mercedes' ML-Class SUV, but seats six instead of five and is 12 inches longer in wheelbase and 15 inches longer overall.

Four models are offered. The R350 has a 268-hp V6, the R500 a 302-hp V8. New for '07 are the R320 CDI with a 215-hp diesel V6, and the R63 with a 507-hp V8. All have a 7-speed automatic transmission; E63 adds manual-shift steering wheel buttons. All Rs have all-wheel drive without low-range gearing. ABS and traction/antiskid control are standard. Front side airbags, rear side airbags, and curtain side airbags that cover all three seating rows are standard. Seating is in a 2-2-2 arrangement, with folding 2nd-row buckets and a folding 50/50 split 3rd-row bench. Standard for R63, optional otherwise, are leather upholstery, navigation system, load-leveling suspension, and Mercedes Tele Aid assistance.