A new diesel engine option marks 2006 for Chevrolet's cargo vans. Express and the GMC Savana share the same basic design and come in passenger and cargo models. Half-ton Express 1500s come only in regular length. Three-quarter-ton 2500s and one-ton 3500s come in regular or extended length. All versions have rear-wheel drive. All-wheel drive is available on 1500s. All models have two swing-open rear cargo doors and, on the passenger side, either 60/40 hinged doors or a sliding door. Optional on all models are the 60/40 doors on the driver side. Regular-length passenger vans seat up to 12, extendeds up to 15. Front seats are buckets; others are benches, which can be removed. Cargo models have front buckets along with metal side and rear panels in place of windows.

A 195-hp V6 engine is standard. Three gasoline V8s of 285, 295, and 345 hp are offered. Newly optional on 2500 and 3500 cargo models is a 250 hp turbodiesel V8. All Express vans have a 4-speed automatic transmission. ABS is standard. GM's Stabilitrak traction/antiskid control is standard on passenger models, unavailable on cargo versions. No side airbags are offered.