Nissan's first "crossover" SUV is a 5-passenger V6 wagon built on its Altima sedan platform. Murano aims at the car-based likes of the Toyota Highlander, which it matches in general size except for standing as much as 4 inches lower despite standard 18-inch wheels. The only engine is a 3.5-liter V6 shared with various Nissan cars. The sole transmission is a continuously variable automatic, which, like other CVTs, provides a near-infinite range of gear ratios. Front-wheel drive or all-wheel drive are offered. Leaving off-road duty to its truck-based Pathfinder SUV, Nissan does not fit Murano with low-range gearing, though a console button locks its AWD into a 50-50 power split for extra traction up to 30 mph. Antilock 4-wheel disc brakes are standard, as are front torso side airbags and front and rear curtain side airbags.

Offered in SL and uplevel SE trim, Murano has a liftgate without separate opening glass. The SE adds a firmer suspension and 6-spoke alloy wheels vs. 5 spoke. Xenon headlamps are standard on SE and optional on SL. An antiskid/traction-control system is optional on both. A tilt steering wheel and dual-zone climate control are standard. Options include power-adjustable pedals, leather upholstery, heated front seats, and rear DVD entertainment. No 3rd-row seating is offered. Nissan says AWD is ordered on 65 percent of Muranos and that SLs account for 85 percent of sales. Towing capacity is 3500 lb.